Voclosporin in lupus nephritis: a profile of its use

<div><b>Acknowledgements </b></div><div>The manuscript was reviewed by: S Mirkov, University of Otago School of Pharmacy, Dunedin, New Zealand; A. Singh, All India Institute of Medical Sciences Raipur, Raipur, Chhattisgarh, India;. During the peer review process, Aurinia Pharmaceuticals, the marketing authorization holder of voclosporin, was also offered an opportunity to provide a scientific accuracy review of their data. Changes resulting from comments received were made on the basis of scientific and editorial merit.</div><div><br></div><div><b>Declarations</b></div><div><b><br></b></div><div><b>Funding</b> The preparation of this review was not supported by any external funding.</div><div><br></div><div><b>Authorship and conflict of interest </b>E. S. Kim is a contracted employee of Adis International Ltd/Springer Nature and S.J. Keam is a salaried employee of Adis International Ltd/Springer Nature and declare no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.</div><div><br></div><div>Additional information about this Adis Drug Review can be found <a href="http://www.springer.com/gp/adis/products-services/adis-journals-newsletters/adis-drug-reviews"><b>here</b></a>.<br></div><div><br></div><div><b>Abstract</b></div><div>Voclosporin (Lupkynis™), a novel calcineurin inhibitor, is effective as an add-on to background immunosuppressive therapy in adults with active lupus nephritis. Voclosporin, in combination with mycophenolate mofetil and low-dose steroids, achieved higher complete renal response rates in adults with active lupus nephritis than mycophenolate mofetil and low-dose steroids alone. Voclosporin treatment led to early and sustained reductions in proteinuria. Voclosporin was generally well tolerated, with no unexpected adverse events.<br></div><div><br></div><div><p><b>©</b> Springer Nature Switzerland AG 2022<b></b></p></div><div><br></div>