Rimegepant orally disintegrating tablets in the acute treatment of migraine: a profile of their use
Funding The preparation of this review was not supported by any external funding.
Authorship and conflict of interest E. Kim is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. K.A. Lyseng-Williamson is the Editor of Drugs & Therapy Perspectives, was not involved in any publishing decisions for this manuscript, and is a salaried employee of Adis International Limited/Springer Nature. She has no other conflicts of interest to declare. All authors contributed to the review and are responsible for the article content.
Ethics approval, consent to participate, consent for publication, availability of data and material, code availability Not applicable.
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Rimegepant orally disintegrating tablets (ODT) for
sublingual or oral use (Nurtec™ ODT) are
a valuable option for the acute treatment of migraine ± aura in adults, especially those
with contraindications, treatment failure, or tolerability issues with
triptans. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor
antagonist, and is the first, and currently only, drug in this class available
as an ODT formulation in the USA. A single sublingual dose of rimegepant ODT
75 mg provided freedom from pain, freedom from the most bothersome migraine
symptoms (e.g., nausea, phonophobia, photophobia), and freedom from functional
disability at 2-h post dose relative to placebo in adults with a migraine
attack with pain of moderate or severe intensity ± aura. Beneficial effects on migraine were
provided as early as 1-h post dose,) and were sustained for 2–48 h. Rimegepant ODT
was well tolerated, with a tolerability profile similar to that of placebo, with
no reports of serious, cardiovascular, or hepatic adverse events in patients
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