Adis Journals
RelugolixEstradiolNorethisterone (Norethindrone) Acetate in Uterine Fibroids.mp4 (62.48 MB)

Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids

Download (62.48 MB)
Version 2 2023-10-19, 01:29
Version 1 2022-10-31, 22:10
online resource
posted on 2023-10-19, 01:29 authored by Yahiya Y. Syed


Funding The preparation of this review was not supported by any external funding.

Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.

Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable

Additional information about this Adis Drug Review can be found here.


An oral fixed-dose combination of relugolix/estradiol/norethisterone (also known as norethindrone) acetate ( Ryeqo®; Myfembree ®) has been approved for the management of heavy menstrual bleeding associated with uterine fibroids in the USA and management of moderate to severe symptoms of uterine fibroids in the EU. Relugolix is a gonadotropin releasing hormone (GnRH) receptor antagonist that decreases serum estradiol and progesterone concentrations to postmenopausal levels. The addition of estradiol/norethisterone acetate to relugolix ameliorates relugolix-induced bone loss and hot flush. In the two phase 3 LIBERTY trials, relugolix + estradiol/norethisterone substantially decreased menstrual bleeding and improved a range of other uterine fibroid symptoms in women with uterine fibroids-associated heavy menstrual bleeding. The combination was generally well tolerated, with vasomotor symptoms being the most common adverse reaction. Treatment with this combination for over up to 2 years did not induce a clinically meaningful bone loss in the majority of women. Relugolix/estradiol/norethisterone acetate, with its convenient once-daily administration, is a useful addition to current pharmacological treatment options for premenopausal women with symptomatic uterine fibroids.

Video Abstract, Script and Slides 

The video abstract, script and slide deck of images from the video, which have been peer reviewed and were uploaded to Figshare after the Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate in Uterine Fibroids Adis Drug Evaluation was published, are sponsored by Myovant GmbH and Pfizer.

The script and slide deck can be found here.

© Springer Nature Switzerland AG 2022