RTS,S/AS01 malaria vaccine (Mosquirix®): a profile of its use
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
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RTS,S/AS01 (Mosquirix®), the first malaria vaccine, is indicated for the active immunisation of children against malaria caused Plasmodium falciparum. In a phase 3 trial, RTS,S/AS01 showed efficacy against P. falciparum malaria, with an acceptable safety and tolerability profile in children aged 6 weeks to 17 months. The efficacy was greater in children aged 5–17 months than in infants aged 6–12 weeks. In another phase 3 trial, RTS,S/AS01 was noninferior to chemoprevention in preventing seasonal malaria in children. WHO recommends a 4-dose schedule of RTS,S/AS01 for the prevention of P. falciparum malaria in children from 5 months of age living in African regions with moderate to high malaria transmission, with an optional 5-dose schedule for seasonal malaria. Preliminary results from large pilot studies in Africa show that RTS,S/AS01 substantially reduces malaria episodes, increases equity in access to malaria prevention, is highly cost effective and can be delivered through the routine national immunization programmes.
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