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Netarsudil Ophthalmic Solution 0.02%: First Global Approval

online resource
posted on 2018-04-11, 03:40 authored by Sheridan M. Hoy
Funding: The preparation of this review was not supported by any external funding.

Conflicts of interest: During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sheridan Hoy is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.

Additional information about this Adis Drug Review can be found here.


Netarsudil ophthalmic solution 0.02% (RHOPRESSA®) [hereafter referred to as netarsudil 0.02%] is a Rho-associated protein kinase inhibitor that is thought to lower intraocular pressure (IOP) by increasing aqueous humour outflow through the trabecular meshwork. It has been developed by Aerie Pharmaceuticals and was recently approved in the USA for the reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension. The recommended dosage is one drop in the affected eye(s) once daily in the evening. Phase III development in Canada and the EU and phase II development in Japan are underway for this indication. This article summarizes the milestones in the development of netarsudil 0.02% leading to this first approval for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Access to the full article can be found here.

© Springer International Publishing AG, part of Springer Nature 2018


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