Linaclotide in constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: a profile of its use in the USA

<div>Compliance with Ethical Standards</div><div><br></div><div><i>Funding:</i> The preparation of this review was not supported by any external funding.</div><div><br></div><div><i>Conflicts of interest:</i> Kate McKeage is a contracted employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest</div><div><br></div><div>Additional information about this Adis Drug Review can be found <b><a href="http://www.springer.com/gp/adis/products-services/adis-journals-newsletters/adis-drug-reviews">here</a>.</b></div><div><br></div><div>Abstract</div><div><br></div><div>Linaclotide (Linzess) is a synthetic guanylate cyclase C agonist that acts locally in the gastrointestinal tract to increase intestinal fluid levels, increase colonic transit, and reduce peripheral pain. In adults with constipation-predominant irritable bowel syndrome (IBS-C) or chronic idiopathic constipation (CIC), once-daily oral linaclotide 290 lg (IBS-C), or 145 or 72 lg (CIC), significantly improved stool frequency and consistency, abdominal pain and bloating, and health-related quality-oflife. Linaclotide is generally well tolerated and, consistent with its therapeutic action, diarrhea is the most common adverse event. Access to the full article can be found <b><a href="https://link.springer.com/article/10.1007/s40267-017-0448-0">here</a>.</b></div><div><br></div><div>© Springer International Publishing AG, part of Springer Nature 2017</div>