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Insulin degludec/liraglutide in type 2 diabetes: a profile of its use

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posted on 29.04.2020, 09:39 authored by Young-A Heo

Compliance with Ethical Standards

Disclosure: The preparation of this review was not supported by any external funding.

Conflicts of interest: Young-A Heo is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest.

Additional information about this Adis Drug Review can be found here

Subcutaneous insulin degludec/liraglutide (Xultophy) is a titratable, fixed-ratio combination of a long-acting insulin analogue and a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that is approved in several countries, including in the USA and those in the EU for the treatment of type 2 diabetes (T2D) as add-on therapy. In clinical and real-world studies in insulin-naïve or -experienced adults with inadequately controlled T2D, once-daily insulin degludec/liraglutide as add-on therapy to oral antidiabetic drugs consistently provided effective and durable glycaemic control, and delayed the time to treatment intensification. It also reduced the risk of hypoglycaemia and bodyweight gain compared with basal or basal-bolus insulin therapy. Insulin degludec/liraglutide is generally well tolerated and offers the convenience of once-daily administration of two injectable antidiabetic drugs.