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Bempedoic Acid: A Review in Cardiovascular Risk Reduction in Statin-Intolerant Patients

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posted on 2025-01-14, 22:40 authored by Aisling McGuigan, Hannah A. Blair

Funding The preparation of this review was not supported by any external funding.


Authorship and Conflict of interest Aisling McGuigan and Hannah A. Blair are salaried employees of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.


Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.


Additional information about this Adis Drug Review can be found here


Abstract


Oral bempedoic acid (NEXLETOL® in the US; Nilemdo® in the EU) and the fixed dose combination (FDC) of bempedoic acid/ezetimibe (NEXLIZET® in the USA; Nustendi® in the EU) are approved to reduce cardiovascular (CV) risk in statin‑intolerant patients who are at high risk for, or have, CV disease. A first-in-class therapy, bempedoic acid inhibits the adenosine triphosphate‑citrate lyase (ACL) enzyme in the cholesterol biosynthesis pathway. In the multinational phase III CLEAR Outcomes trial in statin‑intolerant patients, once-daily bempedoic acid 180 mg significantly reduced the risk of the primary endpoint (a four-component major adverse CV event composite of CV death, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization) compared with placebo. Bempedoic acid was generally well tolerated and, unlike statins, was associated with a low incidence of musculoskeletal adverse events (AEs). In conclusion, bempedoic acid as a monotherapy or adjunctive to other lipid-lowering therapies expands the treatment options available for the pharmacological reduction of CV risk in statin-intolerant patients, supporting achievement of low‑density lipoprotein cholesterol (LDL‑C) targets required for CV risk reduction.


© Springer Nature Switzerland AG 2025


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    American Journal of Cardiovascular Drugs

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