Amisulpride: A Review in Post-Operative Nausea and Vomiting

<p><b>Declarations</b></p> <p><b>Funding</b> The preparation of this review was not supported by any external funding.</p> <p><b>Authorship and Conflict of interest</b> Connie Kang and Matt Shirley are salaried employees of Adis International Ltd/Springer Nature, are responsible for the article content and declare no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. </p> <p> </p> <p><b>Ethics Approval, Consent to participate, Consent to publish, Availability of data and material, Code availability</b> Not applicable.</p><p><br></p><p>Additional information about this Adis Drug Review can be found <a href="http://www.springer.com/gp/adis/products-services/adis-journals-newsletters/adis-drug-reviews">here</a>.<br></p><p><br></p><p><br></p><p><b>Abstract</b><br></p><p> </p><p>Amisulpride intravenous (IV) injection (Barhemsys^®; hereafter referred to as IV amisulpride), a selective dopamine receptor antagonist, is approved in the USA as a single IV infusion for the prevention and treatment of post-operative nausea and vomiting (PONV) in adults. Results from placebo-controlled phase III trials showed that IV amisulpride is efficacious both in the prevention of PONV (used either alone or in combination with an antiemetic of a different class) and in the treatment of PONV (irrespective of prior antiemetic prophylaxis status). When administered as a single IV infusion, amisulpride had a tolerability profile that was generally similar to that of placebo, with no significant safety concerns identified. Thus, IV amisulpride is a useful additional option in the prevention and treatment of PONV in adults, particularly for patients who have failed previous antiemetic prophylaxis and for whom effective treatment options may be limited.</p><p>© Springer Nature Switzerland AG 2020</p><p><br></p>