10.6084/m9.figshare.6124421.v1 Katherine A. Lyseng-Williamson Katherine A. Lyseng-Williamson Sarah L. Greig Sarah L. Greig Lesley J. Scott Lesley J. Scott Intravenous minocycline in multidrug-resistant infections: a profile of its use in the USA with a focus on Acinetobacter infections Adis Journals 2018 Intravenous Minocycline Minocin® Infections Gram-positive pathogens Gram-negative pathogens Acinetobacter baumannii Acinetobacter baumannii Infection Adis Drug Review 2018-04-11 00:26:58 Online resource https://adisjournals.figshare.com/articles/online_resource/Intravenous_minocycline_in_multidrug-resistant_infections_a_profile_of_its_use_in_the_USA_with_a_focus_on_Acinetobacter_infections/6124421 <div>Compliance with ethical standards</div><div><br></div><div><i>Funding:</i> The preparation of this review was not supported by any external funding.</div><div><br></div><div><i>Conflicts of interest:</i> K.A. Lyseng-Williamson, S.L. Greig SL, and L.J. Scott are employees of Adis/Springer, are responsible for the article content and declare no conflicts of interest.</div><div><br></div><div>Additional information about this Adis Drug Review can be found <b><a href="http://www.springer.com/gp/adis/products-services/adis-journals-newsletters/adis-drug-reviews">here</a>.</b></div><div><br></div><div>Abstract</div><div><br></div><div>Intravenous (IV) minocycline (Minocin®) is approved in the USA for use in patients with infections due to susceptible strains of many bacteria (e.g. Gram-positive and Gram-negative pathogens, including infections due to Acinetobacter spp.). Minocycline shows antibacterial activity against A. baumannii clinical isolates worldwide, and exhibits synergistic bactericidal activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) A. baumanniiisolates when combined with other antibacterial agents. In retrospective studies, IV minocycline provided high rates of clinical success or improvement, and was generally well tolerated among patients with MDR or carbapenem-resistant A. baumannii infections. Access to the full article can be found <b><a href="https://link.springer.com/article/10.1007/s40267-017-0453-3">here</a>.</b></div><div><br></div><div>© Springer International Publishing AG, part of Springer Nature 2017</div>